Cannabis contains over 100 different cannabinoids, but only a few have been studied in detail. The three most important for health applications are CBD, CBG, and CBN.
What Is the Endocannabinoid System (ECS)?
The ECS is a biological system present in all mammals. It regulates sleep, mood, pain, appetite, immunity, and inflammation. Cannabinoids from hemp act on this system.
CBD (Cannabidiol) – The Most Researched Cannabinoid
- Anxiety and stress – 79.2% of participants report reduced anxiety
- Pain and inflammation – CBD inhibits COX-2 enzyme (same mechanism as ibuprofen)
- Epilepsy – Epidiolex (pure CBD) is the only FDA-approved CBD medication
- Sleep – 66.7% report improved sleep
CBG (Cannabigerol) – The "Stem Cell" of Cannabinoids
CBG is called the "stem cell" because all other cannabinoids are created from CBGA. In the mature plant, it's very rare (below 1%). CBG directly binds to CB1 and CB2 receptors.
- Anti-inflammatory – particularly effective for intestinal inflammation (Crohn's, colitis)
- Antibacterial – effective against MRSA
- Neuroprotective – protects nerve cells
CBN (Cannabinol) – The Sleep Cannabinoid
CBN is formed through THC degradation. It's mildly psychoactive and primarily known for its sedative effect.
- Sleep and sedation – CBN is the strongest natural sedative among cannabinoids
- Pain – CBN activates capsaicin receptors (TRPV2)
Comparison: CBD vs CBG vs CBN
| Property | CBD | CBG | CBN |
|---|---|---|---|
| Full name | Cannabidiol | Cannabigerol | Cannabinol |
| Presence in plant | 15–25% | <1% (rare) | Traces (from THC) |
| Psychoactivity | No | No | Mild (1/10 of THC) |
| Best for sleep | Moderate | Minimal | Excellent (sedative) |
| Best for pain | Excellent | Good | Good (+ sedation) |
| Best for anxiety | Excellent | Moderate | Moderate |
| Best for inflammation | Excellent | Excellent (esp. gut) | Good |
Which Cannabinoid Is Right for You?
- For ANXIETY AND STRESS → CBD (5–20mg daily, under the tongue)
- For CHRONIC PAIN → CBD + CBG combination (our oil has both!)
- For INSOMNIA → CBN (or CBD in evening as alternative)
- For DIGESTIVE ISSUES → CBG (anti-inflammatory for the gut)
- For GENERAL WELLNESS → Full Spectrum CBD oil (entourage effect)
FAQ
What does "Full Spectrum" mean?
Why does your oil have so much CBG?
Is CBD legal in Croatia?
Sources
- Arthur P, Kalvala AK, Surapaneni SK, Singh MS (2024). Applications of Cannabinoids in Neuropathic Pain: An Updated Review.. Critical reviews in therapeutic drug carrier systems. PMID: 37824417
- Blebea NM, Pricopie AI, Vlad RA, Hancu G (2024). Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use.. International journal of molecular sciences. PMID: 38673788
- Queiroz CM, de Oliveira Koren L, da Silva CRP, Ribeiro S, Silva SRB (2025). Chemical diversity, receptor binding affinity, and pharmacology of phytocannabinoids: Insights into neuronal mechanisms.. Progress in brain research. PMID: 40967679
- Salami SA, Martinelli F, Giovino A, Bachari A, Arad N, Mantri N (2020). It Is Our Turn to Get Cannabis High: Put Cannabinoids in Food and Health Baskets.. Molecules (Basel, Switzerland). PMID: 32899626
- Solano-Orrala D, Silva-Cullishpuma DA, Díaz-Cruces E, Gómez-López VM, Toro-Mendoza J, Gomez d'Ayala G (2024). Exploring the Potential of Nonpsychoactive Cannabinoids in the Development of Materials for Biomedical and Sports Applications.. ACS applied bio materials. PMID: 39563525
Note: This article is for informational purposes only, does not constitute medical advice and does not replace consultation with a doctor. Consult a doctor before taking any food supplement — especially with chronic conditions, pregnancy or breastfeeding.
